Marijuana Cannabinoid (CBD) Strengthens Bones and Accelerates Healing of Fractures, without Psychotropic Effects

The researcher Yankel Gabet explained:

 “We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue. After being treated with CBD, the healed bone will be harder to break in the future.”

The team of experts inflicted mild femoral fractures on rats, and then gave an injection of CBD to some of them, while others received CBD plus tetrahydrocannabinol (THC, the ingredient that causes the marijuana high). They analyzed the healing between them and the rats that had not received any marijuana chemicals. Their conclusion was that rats injected with CBD experienced the same effects, regardless of the addition of THC.
Gabet added:

“We found CBD alone to be sufficiently effective in enhancing fracture healing. Other studies have also shown CBD to be a safe agent, which leads us to believe we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing.”

The same team previously found that the body contains receptors which respond to cannabinoid compounds, and they are not confined to the brain. This study showed that the skeleton has cannabinoid receptors which trigger bone formation and prevent bone loss, and the second study just confirmed this.

“We only respond to cannabis because we are built with intrinsic compounds and receptors that can also be activated by compounds in the cannabis plant.”

This study is just a part of all research dedicated to the medical benefits of marijuana compounds, and new findings might stimulate researchers to analyze the positive effects of marijuana in the treatment of osteoporosis or other bone diseases.

“The clinical potential of cannabinoid-related compounds is simply undeniable at this point. While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity.”

The medical properties of marijuana are numerous, and it is primarily used to boost appetite in the case of AIDS, to lower the side-effects of chemotherapy, and to soothe chronic pain. Numerous studies claim that it can regulate blood sugar, decelerate the HIV progression, and treat multiple sclerosis and Parkinson’s disease.
Researchers have shown that CBD suppresses seizures, inhibits the metastasis of many aggressive cancers, and destroys leukemia cells.
The journal Neuropsychopharmacology published a 2013 study which discovered that CBD is as effective as one antipsychotic drug, which is commonly used in the treatment of schizophrenia and paranoia but causes no side-effects. Other studies have also found that CBD can be used as a safe antipsychotic.
Marijuana is still technically illegal under U.S. federal law, but 17 U.S. states allow the use of CBD for research or for limited medical functions. Plus, the laws of 23 other countries permit the medical use of marijuana.
Marijuana is still classified as having “no currently accepted medical use” by the federal government. What might be a change in this approach is the recent decision of the FDA to approve the use of CBD extracts an experimental treatment for the Dravet syndrome, a rare form of childhood epilepsy.

What are Cannabinoids?

Cannabinoids are a group of active compounds found in marijuana.

While marijuana contains many different compounds, cannabinoids are undeniably the most important.

Cannabinoids are responsible for marijuana’s effects on the body — and the reason users get high. They’re also the reason why medical marijuana works to alleviate so many symptom-related ailments.

However, the relationship between cannabinoids and our bodies is complex.

Because so many people use cannabis for recreational or medicinal purposes, a little information on cannabinoids can go a long way towards understanding how marijuana affects your brain and body.

Cannabis and Cannabinoids


The cannabis plant, also known as marijuana, contains over 500 natural compounds. Cannabinoids happen to make up at least 85 of those compounds, according to recent research. And while some cannabinoids are psychoactive, others are not.

Out of the 85 cannabinoids, two stand out: tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, known for its psychoactive properties, is the reason you feel buzzed after ingesting marijuana.

Most strains of marijuana sold on the market today are cultivated with higher levels of THC. While THC has medicinal benefits, too much can trigger anxiety and paranoia in some — particularly in novice users.

CBD is a non-psychoactive cannabinoid and actually works to calm your high. It’s also believed that CBD has numerous medicinal benefits, such as anti-inflammatory properties and the ability to protect your neurons from injury or degeneration.

How Do They Work?

In the early 1990s, scientists discovered the link between cannabis and feeling high.

Your brain creates its own set of cannabinoids — similar to those found in cannabis — via the endocannabinoid system. The endocannabinoid system, named after Cannabis sativa, is responsible for many important functions, such as appetite, sleep, emotion and movement.


Cannabinoids work by interacting with specific receptors. These receptors are located within different parts of the body, such as the central nervous system and immune system.

Cannabinoids activate two types of receptors: CB1 receptors, located within the nervous system, the brain and nerve endings, and CB2 receptors, located within the immune system.

When marijuana enters your body, THC activates the endocannabinoid system by attaching to cannabinoid receptors. As a result, your reaction time slows, memory is affected, and judgment is impaired. Because of where CB1 receptors are located in the brain, you begin to feel high.

Common Cannabinoids


Tetrahydrocannabinol (THC) is the most common psychoactive cannabinoid. It is best known for causing the high you get from smoking marijuana. However, it also seems to have a number of medical applications, such as pain relief and the ability to improve appetite.

Cannabidiol (CBD) is the second most common cannabinoid. Although it has no psychoactive effects, it appears to improve mood and alleviate pain. CBD has received a lot of attention lately because of its antipsychotic effect that calms the nervous system. Studies suggest that it may help with epilepsy, schizophrenia and a number of other ailments.

Cannabinol (CBN) is created from THC when cannabis is exposed to air — through a process called oxidization. CBN on its own provides a mild psychoactive effect, but when combined with THC can make you feel drowsy and induce sleep.

Cannabigerol (CBG), a non-psychoactive cannabinoid, is the building block for THC and CBD. It has been shown to reduce intraocular pressure, making it ideal for glaucoma patients.

While each cannabinoids works independently, used together, they create an entourage effect, which multiplies the benefits of each individual cannabinoid.
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